Composition:
Finasteride.
Description:
Tablets
Proscar contains finasteride, which is described chemically as:
N-(1,1-dimethylethyl) -3-oxo-4 -aza-5 a-androst- 1-ene- 17b- carboxamide. The
empirical formula is C 23H 36N 2O2 and the molecular weight is 372.55.
Proscar (finasteride, MSD), a synthetic 4-azasteroid
compound, is a specific inhibitor of Type II 5-alpha reductase, an
intracellular enzyme which metabolises testosterone into the more potent
androgen dihydrotestosterone (DHT). In benign prostatic hyperplasia (BPH),
enlargement of the prostate gland is dependent upon the conversion of
testosterone to DHT within the prostate. Proscar is highly effective in
reducing circulating and intraprostatic DHT. Finasteride has no affinity for
the androgen receptor.
Pharmacology and Pharmacokinetics:
Please read the original package insert for details!
Indications:
Proscar is indicated for the treatment of patients with symptomatic benign
prostatic hyperplasia (BPH) with an enlarged prostate.
Conta-indications:
Proscar is contraindicated in the following: :
·
Use in
women when they are or may potentially be pregnant
·
*
Hypersensitivity to any component of this product.
Proscar is not indicated for use in women or children.
Warnings and Precautions:
Please read the original package insert for details!
Adverse Reaction:
Proscar is well tolerated.
Please read the original package insert for details!
Dosage and Administration:
The recommended dosage is one 5\mg tablet daily with or without food.
Dosage in Renal Insufficiency: Adjustments in dosage are not
necessary in patients with varying degrees of renal insufficiency (creatinine
clearances as low as 9\mL/min) as pharmacokinetic studies did not indicate any
change in the disposition of finasteride.
Dosage in the Elderly: No adjustment in dosage is required although
pharmacokinetic studies indicated the elimination of finasteride is somewhat
decreased in patients more than 70 years of age.
Pack:
Proscar 5mg, a pack of 30 tablets in a blister package.
Storage and Handling:
Store below
30&C and protect from light.
LINK:
www.proscar.com