(Adapalene)
Chemical
Name: 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic
acid.
Molecular Formula: C28H28O3
Molecular Weight: 412.52
Description:
Differin
topical gel is a smooth white gel containing 1\mg/g adapalene. The gel contains
carbomer 980, propylene glycol, poloxamer, disodium edetate, methyl
hydroxybenzoate, phenoxyethanol, sodium hydroxide and purified water.
Pharmacology:
Pharmacodynamic properties: Adapalene is a chemically stable
compound with retinoid-like pharmacological activity. Biochemical and
pharmacological profile studies have demonstrated that adapalene is a potent
modulator of cellular differentiation, keratinisation and inflammatory
processes all of which represent important features in the pathology of acne
vulgaris. Mechanistically, adapalene binds to specific retinoic acid nuclear
receptors but unlike tretinoin, does not bind to the cytosolic receptor
protein. Although the exact mode of action of adapalene is unknown current
evidence suggests that topical adapalene normalises the differentiation of
follicular epithelial cells resulting in decreased microcomedone formation.
Adapalene inhibits the chemotactic (directional) and chemokinetic (random)
responses of human polymorphonuclear leucocytes in in vitro assay
models. It also inhibits the metabolism of arachidonic acid by lipoxidation, to
inflammatory mediators.
Therapeutic indications:
Differin
gel 0.1% is indicated for the topical treatment of comedo, papular and pustular
acne (acne vulgaris) of the face, chest or back.
Contra-indications:
Not to be used in patients who are hypersensitive to any of the ingredients.
Dosage and Administration:
A thin film of Differin Topical Gel should be applied to the affected areas
once a day before bedtime and after washing avoiding the eyes lips and mucous
membranes. The affected areas should be dry before application.
Storage:
Store below
25C and out of reach of children. Avoid exposure to excessive heat.
Pack:
Collapsible aluminium tube (30g) coated internally with an epoxy-phenolic resin
and fitted with a white polypropylene screw cap.
LINK:
http://healthanswers.telstra.com/drugdata/DrugDetails.asp?ID=2857