(OSPAMOX)
(Other Brand names: Amoxil;
Biomox; Polymox; Trimox; Wymox; )
Composition:
Amoxycillin Trihydrate.
Microbiology:
Ospamox
differs in vitro from benzylpenicillin in the Gram-negative spectrum.
Ospamox has the same Gram-positive and Gram-negative spectrum as ampicillin.
In vitro most strains of Haemophilus influenzae, Neisseria
gonorrhoeae, Neisseria meningitidis, Proteus mirabilis, Salmonellae, alpha-
and beta-haemolytic streptococci, Diplococcus pneumoniae,
non-penicillinase producing staphylococci and Streptococcus faecalis,
are sensitive to Ospamox at serum concentrations which may be expected
following the recommended doses. However, some of the organisms were sensitive
to Ospamox only at concentrations
achieved in the urine.
Pharmacokinetics:
Ospamox is
stable in the presence of gastric acid and is rapidly and well absorbed after
oral administration, even in the presence of food. Ospamox diffuses rapidly
into most body tissues and fluids, with the exception of brain and spinal fluid
except when meninges are inflamed.
Ospamox has been shown to diffuse into sputum and saliva and
is excreted mainly via the urine where it exists in a high concentration.
Indications:
It is
indicated for the treatment of the following infections due to susceptible
strains of sensitive organisms:
Skin and Soft Tissues: Staphylococcus, non-penicillinase producing;
Streptococcus; E.coli (see Microbiology).
Respiratory (Acute and Chronic): H.influenzae, Streptococcus; S.pneumoniae;
staphylococcus, non-penicillinase-producing; E.coli (see Microbiology).
Genitourinary Tract (complicated and uncomplicated, Acute
and Chronic): E.coli (see
Microbiology), P.mirabilis and S.faecalis.
Gonorrhoea: N.gonorrhoeae (non-penicillinase producing).
Prophylaxis of endocarditis: Amoxil may be used for the
prophylaxis of bacterial endocarditis in individuals at particular risk, such
as those with a prosthetic heart valve or those who have previously had
endocarditis.
Contra-indications:
Amoxcyillin
is a penicillin and should not be given to patients with a history of
hypersensitivity to beta-lactam antibiotics (eg. penicillins, cephalosporins).
Dosage and Administration:
Normal Renal Function:
Upper respiratory tract infections; genito-urinary tract
infections; skin and soft tissue infections:
Adults - 250\mg every eight hours.
Children (under 20 kg) - 20\mg/kg/day in equally divided
doses every eight hours.
Pack:
Capsules 250mg and Capsules 500mg